Synthetic biology: back to the basics
Realizing the ambitious goals of synthetic biology requires continued efforts in characterizing the foundations.
Cell-line authentication demystified
Some researchers run and hide from the task of authenticating cell lines. A few simple steps save time and money.
Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon
A minimal Mos transposon for integration of transgenes into the Caenorhabditis elegans genome expands the genetic toolbox in this model organism.
Discovering enhancers directly by activity
Two methods are used to identify cis-regulatory sequences by looking at their function.
Principles of genetic circuit design
This Review introduces tools to build transcriptional circuits and explains how the choice of different tools can affect circuit behavior and how its operation can be affected by the cellular host.
Programming biological operating systems: genome design, assembly and activation
This Perspective takes the reader through the important steps in bacterial genome assembly and activation and concludes with an outlook on how customized genomes may be achieved.
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Nature Methods provides techniques for life scientists and chemists. The publication is dedicated to publishing novel methods together with significant advances to tried and tested techniques allowing researchers to perform faster, better and more efficient experimental research.